PSORALEN PROTEIN PHOTOCHEMISTRY - A FORGOTTEN FIELD

被引：78

作者：

SCHMITT, IM ^{[1
]}

CHIMENTI, S ^{[1
]}

GASPARRO, FP ^{[1
]}

机构：

[1] YALE UNIV, DEPT DERMATOL, PHOTOBIOL LAB, NEW HAVEN, CT 06510 USA

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1995年 / 27卷 / 02期

基金：

美国国家卫生研究院;

关键词：

8-METHOXYPSORALEN; PROTEIN PHOTOADDUCTS; PROTEIN PROCESSING; PHOTOCHEMOTHERAPY; MYCOSIS FUNGOIDES;

D O I：

10.1016/1011-1344(94)07101-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

8-Methoxypsoralen in combination with long wavelength ultraviolet light is employed for the treatment of several cutaneous disorders, such as psoriasis, vitiligo and mycosis fungoides. It is common to attribute the efficacy of the photochemotherapy to the formation of psoralen DNA photoadducts. Thus, the main research effort has been directed towards the elucidation of nucleic acid photochemistry and related subsequent events (mutagenicity, toxicity). However, psoralens have been shown to undergo photoaddition reactions with other cellular components. In this review the status of psoralen-DNA photobiology is briefly summarized. The main focus, however, is on a survey of psoralen photochemical modification of proteins and the ways by which these additional photobiological events can impact the antigenicity and potentially immunogenicity of treated cells. Some preliminary results show the extent of psoralen-amino acid photoadduct formation and their impact on enzymatic processing.

引用

页码：101 / 107

页数：7

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