CENTRIFUGAL COUNTERCURRENT CHROMATOGRAPHY, A PROMISING MEANS OF MEASURING PARTITION-COEFFICIENTS

被引：36

作者：

VALLAT, P

ELTAYAR, N

TESTA, B

SLACANIN, I

MARSTON, A

HOSTETTMANN, K

机构：

[1] UNIV LAUSANNE,ECOLE PHARM,INST CHIM THERAPEUT,PL CHATEAU,CH-1005 LAUSANNE,SWITZERLAND

[2] UNIV LAUSANNE,ECOLE PHARM,INST PHARMACOGNOSIE & PHYTOCHIM,CH-1005 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 504卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(01)89544-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Centrifugal counter-current chromatography (CCCC) was examined as a means of measuring lipophilicity values. Using an aqueous buffer as the stationary phase and 1-octanol as the eluent, seventeen solutes of widely different structure and of log Doct [log (distribution coefficient) at pH 7.41 spanning 2.5 units were examined. A very good correlation was found with literature log P [log (partition coefficient) of neutral species] values measured by the classical shake-flask method. The efficiency and precision of the CCCC method makes it a promising technique for measuring lipophilicity. © 1990.

引用

页码：411 / 419

页数：9

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