CONCENTRATIONS OF CEFIXIME IN BRONCHIAL-MUCOSA AND SPUTUM AFTER 3 ORAL MULTIPLE DOSE REGIMENS

被引：20

作者：

BALDWIN, DR ^{[1
]}

ANDREWS, JM ^{[1
]}

ASHBY, JP ^{[1
]}

WISE, R ^{[1
]}

HONEYBOURNE, D ^{[1
]}

机构：

[1] DUDLEY RD GEN HOSP,DEPT MED MICROBIOL,BIRMINGHAM B18 7QH,W MIDLANDS,ENGLAND

来源：

THORAX | 1990年 / 45卷 / 05期

关键词：

D O I：

10.1136/thx.45.5.401

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In a study of 58 patients the concentrations of cefixine, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The antibiotic was often undetectable in sputum despite a highly sensitive assay.

引用

页码：401 / 402

页数：2

共 12 条

[1]

BAUERNFEIND A, 1985, 14TH P WORKSH INT C, P11

[2] PENETRATION OF ANTIBIOTICS INTO THE RESPIRATORY TREE [J].

BERGOGNEBEREZIN, E .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1981, 8 (03) :171-174

[3] FIMBRIAL AND NON-FIMBRIAL HEMAGGLUTININS OF ESCHERICHIA-COLI [J].

DUGUID, JP ;

CLEGG, S ;

WILSON, MI .

JOURNAL OF MEDICAL MICROBIOLOGY, 1979, 12 (02) :213-227

[4] THE MUCOSAL EPITHELIUM OF THE RESPIRATORY TRACT IN MUCO-PURULENT BRONCHITIS CAUSED BY HAEMOPHILUS-INFLUENZAE [J].

HERS, JFP ;

MULDER, J .

JOURNAL OF PATHOLOGY AND BACTERIOLOGY, 1953, 66 (01) :103-&

[5] EVALUATION OF THE PENETRATION OF CIPROFLOXACIN AND AMOXYCILLIN INTO THE BRONCHIAL-MUCOSA [J].

HONEYBOURNE, D ;

ANDREWS, JM ;

ASHBY, JP ;

LODWICK, R ;

WISE, R .

THORAX, 1988, 43 (09) :715-719

[6] PENETRATION OF CEFACLOR INTO BRONCHIAL-MUCOSA [J].

MARLIN, GE ;

NICHOLLS, AJ ;

FUNNELL, GR ;

BRADBURY, R .

THORAX, 1984, 39 (11) :813-817

[7] PENETRATION OF PIPERACILLIN INTO BRONCHIAL-MUCOSA AND SPUTUM [J].

MARLIN, GE ;

BURGESS, KR ;

BURGOYNE, J ;

FUNNELL, GR ;

GUINNESS, MDG .

THORAX, 1981, 36 (10) :774-780

[8]

PALMER LB, 1987, CLIN CHEST MED, V8, P455

[9]

PENNINGTON JE, 1981, REV INFECT DIS, V3, P67

[10]

THADEPALLI H, 1984, ANTIMICROBIAL THERAP, P439

← 1 2 →