L-SERINE OBTAINED BY METHANOL ADDITION IN BATCH CRYSTALLIZATION

被引：33

作者：

CHARMOLUE, H ^{[1
]}

ROUSSEAU, RW ^{[1
]}

机构：

[1] GEORGIA INST TECHNOL,SCH CHEM ENGN,ATLANTA,GA 30332

来源：

AICHE JOURNAL | 1991年 / 37卷 / 08期

关键词：

D O I：

10.1002/aic.690370802

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The solubility of L-serine in water was measured as a function of temperature, and the solubility in methanol-water solutions was determined as a function of temperature and methanol concentration. Solubility in aqueous solutions was found to be a linear function of temperature. Additionally, a statistical design of experiments was used to identify the kinetic variables that influence the purity of L-serine crystals recovered by batch crystallization. Agitation and the rate at which super-saturation was generated through cooling and methanol addition were found to influence the methanol content of the recovered crystals. The size of the recovered crystals also was found to depend on agitation and the rate at which methanol was added to the L-serine mother liquor.

引用

页码：1121 / 1128

页数：8

共 28 条

[1]

ARMSTRONG FB, 1983, BIOCHEMISTRY

[2]

BALAREW C, 1982, IND CRYSTALLIZATION

[3] CRYSTALLIZATION OF AMINO-ACIDS [J].