BETA-2-MICROGLOBULIN AND HELICOBACTER-PYLORI INFECTION IN UREMIC DIALYZED PATIENTS

被引：9

作者：

CONZ, PA ^{[1
]}

DANTE, S ^{[1
]}

BERNARDINI, D ^{[1
]}

BERTONCELLO, V ^{[1
]}

LAGRECA, G ^{[1
]}

BEVILACQUA, PA ^{[1
]}

机构：

[1] S BORTOLO HOSP,GASTROENTEROL SERV,VICENZA,ITALY

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1992年 / 7卷 / 02期

关键词：

BETA-2-MICROGLOBULIN; HELICOBACTER-PYLORI; UREMIC GASTRITIS;

D O I：

10.1111/j.1440-1746.1992.tb00960.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic gastritis in patients with chronic renal failure may have different causes and mechanisms. Recent observations suggest that severe gastritis often found in uraemic patients might be related to Helicobacter pylori (HP) infection. In chronic gastritis HP has been found in the mucus and on the epithelial cell surface of gastric foveolas. Significant infiltration of the subepithelial gastric layer by polymorphonuclear leucocytes has been described. Moreover, beta-2-microglobulin deposits have been found by immunohistochemical methods in the subepithelial layer of gastric mucosa of uraemic dialysed patients with active chronic gastritis and HP infection. Similar findings have also been demonstrated in gastric biopsies from patients with HP positive active chronic gastritis and normal renal function. Since HP infection is associated with significant leucocyte infiltration, it is hypothesized that the inflammatory process causes the release of beta-2-M from the surface of the leucocytes and its subsequent deposition at gastric level.

引用

页码：191 / 193

页数：3

共 19 条

[1]

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[2]

CAMPYLOBACTER-PYLORI IN UREMIC DIALYZED PATIENTS [J].