CLONING OF A CDNA-ENCODING A RECEPTOR RELATED TO THE FORMYL PEPTIDE RECEPTOR OF HUMAN NEUTROPHILS

被引：38

作者：

PEREZ, HD ^{[1
]}

HOLMES, R ^{[1
]}

KELLY, E ^{[1
]}

MCCLARY, J ^{[1
]}

ANDREWS, WH ^{[1
]}

机构：

[1] BERLEX BIOSCI,DEPT MOLEC BIOL,S SAN FRANCISCO,CA 94080

来源：

GENE | 1992年 / 118卷 / 02期

关键词：

INFLAMMATION; CHEMOTAXIS; G-PROTEIN; HL-60; CELLS; BONE MARROW;

D O I：

10.1016/0378-1119(92)90208-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We cloned a cDNA (RFP) encoding a receptor (RFP) related (70% overall nucleotide homology) to the formyl peptide receptor of human neutrophils (hFPR). RFP is a seven-transmembrane-domain receptor and its distribution is limited to myeloid cells. Domain sequence comparison with hFPR reveals highly conserved regions and provides clues to putative domains involved in ligand binding and receptor desensitization.

引用

页码：303 / 304

页数：2

共 4 条

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[3]

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[4] DEFECTIVE POLYMORPHONUCLEAR LEUKOCYTE FORMYL PEPTIDE RECEPTOR(S) IN JUVENILE PERIODONTITIS [J].

PEREZ, HD ;

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ARMITAGE, G ;

WINKLER, J .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) :971-976

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