REFINED LOCALIZATION OF THE BRANCHIOOTORENAL SYNDROME GENE BY LINKAGE AND HAPLOTYPE ANALYSIS

被引：28

作者：

NI, L

WAGNER, MJ

KIMBERLING, WJ

PEMBREY, ME

GRUNDFAST, KM

KUMAR, S

DAIGER, SP

WELLS, DE

JOHNSON, K

SMITH, RJH

机构：

[1] UNIV IOWA, DEPT OTOLARYNGOL HEAD & NECK SURG, MOLEC OTOLARYNGOL RES LABS, IOWA CITY, IA 52242 USA

[2] UNIV HOUSTON, DEPT BIOL, HOUSTON, TX 77204 USA

[3] BOYS TOWN NATL RES HOSP, OMAHA, NE 68131 USA

[4] INST CHILD HLTH, LONDON, ENGLAND

[5] WASHINGTON CHILDRENS HOSP, WASHINGTON, DC USA

[6] UNIV TEXAS, HLTH SCI CTR, CTR GENET, DEPT GENET, HOUSTON, TX USA

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1994年 / 51卷 / 02期

关键词：

D O I：

10.1002/ajmg.1320510222

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Branchiootorenal (BOR) syndrome is a common autosomal dominant form of hearing impairment previously mapped to 8q. This report refines the localization of the BOR syndrome gene by haplotype analysis to the interval flanked by markers D8S553 and D8S286. By multipoint linkage analysis, the disease locus most likely is flanked by markers D8S530 and D8S279. (C) 1994 Wiley-Liss, Inc.

引用

页码：176 / 184

页数：9

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