NON-NMDA-MEDIATED TRANSMISSION OF SOMATOSENSORY-EVOKED POTENTIALS IN THE RAT THALAMUS

被引：9

作者：

BLOCK, F ^{[1
]}

SCHWARZ, M ^{[1
]}

SONTAG, KH ^{[1
]}

机构：

[1] MAX PLANCK INST EXPTL MED,W-3400 GOTTINGEN,GERMANY

来源：

BRAIN RESEARCH BULLETIN | 1993年 / 31卷 / 05期

关键词：

EXCITATORY AMINO ACIDS; VENTROBASAL THALAMIC NUCLEUS; SOMATOSENSORY-EVOKED POTENTIALS; RAT;

D O I：

10.1016/0361-9230(93)90108-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Somatosensory-evoked potentials (SEPs) were recorded from the somatosensory cortex of pentobarbital-anesthetized rats, in response to single electrical stimulation of the contralateral forelimb. The effects of microapplication of the selective N-methyl-D-aspartate (NMDA) antagonist, (-)-2-Amino-7-phosphonoheptanoate (AP7), and of the specific non-NMDA antagonist, 6,7-Dinitro-quinoxaline-2,3-dione (DNQX), in the ventrobasal thalamic nucleus on the amplitudes and latencies of cortical potentials were measured. The injection of DNQX resulted in a decrease in amplitude and an increase in the latency of cortical SEPs. These effects were a) dose dependent over the range 0.1 to 1.0 nmol, b) specific for non-NMDA receptors, and c) site specific. In contrast, microapplications of AP7 did not affect the SEPs. The present findings support the hypothesis that non-NMDA receptors in the ventrobasal thalamic nucleus are involved in the transmission of cortical SEPs.

引用

收藏

页码：449 / 454

页数：6

相关论文

共 24 条

[1] PROCESSING OF SENSORY INFORMATION [J].

ANGEL, A .

PROGRESS IN NEUROBIOLOGY, 1977, 9 :1-122

[2] 6,7-DINITRO-QUINOXALINE-2,3-DION AND 6-NITRO,7-CYANO-QUINOXALINE-2,3-DION ANTAGONIZE RESPONSES TO NMDA IN THE RAT SPINAL-CORD VIA AN ACTION AT THE STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR [J].

BIRCH, PJ ;

GROSSMAN, CJ ;

HAYES, AG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 156 (01) :177-180

[3] CNQX BLOCKS ACIDIC AMINO-ACID INDUCED DEPOLARIZATIONS AND SYNAPTIC COMPONENTS MEDIATED BY NON-NMDA RECEPTORS IN RAT HIPPOCAMPAL SLICES [J].

BLAKE, JF ;

BROWN, MW ;

COLLINGRIDGE, GL .

NEUROSCIENCE LETTERS, 1988, 89 (02) :182-186

[4] EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].

COLLINGRIDGE, GL ;

KEHL, SJ ;

MCLENNAN, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46

[5] THALAMIC NMDA RECEPTORS AND NOCICEPTIVE SENSORY SYNAPTIC TRANSMISSION [J].

EATON, SA ;

SALT, TE .

NEUROSCIENCE LETTERS, 1990, 110 (03) :297-302

[6] QUINOXALINEDIONES SELECTIVELY BLOCK QUISQUALATE AND KAINATE RECEPTORS AND SYNAPTIC EVENTS IN RAT NEOCORTEX AND HIPPOCAMPUS AND FROG SPINAL-CORD INVITRO [J].

FLETCHER, EJ ;

MARTIN, D ;

ARAM, JA ;

LODGE, D ;

HONORE, T .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (02) :585-597

[7] SLOW EXCITATORY POSTSYNAPTIC CURRENTS MEDIATED BY N-METHYL-D-ASPARTATE RECEPTORS ON CULTURED MOUSE CENTRAL NEURONS [J].

FORSYTHE, ID ;

WESTBROOK, GL .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 396 :515-533

[8] ANTAGONISM OF GLUTAMATE-INDUCED AND SYNAPTIC EXCITATIONS OF THALAMIC NEURONES [J].

HALDEMAN, S ;

HUFFMAN, RD ;

MARSHALL, KC ;

MCLENNAN, H .

BRAIN RESEARCH, 1972, 39 (02) :419-&

[9] QUINOXALINEDIONES - POTENT COMPETITIVE NON-NMDA GLUTAMATE RECEPTOR ANTAGONISTS [J].

HONORE, T ;

DAVIES, SN ;

DREJER, J ;

FLETCHER, EJ ;

JACOBSEN, P ;

LODGE, D ;

NIELSEN, FE .

SCIENCE, 1988, 241 (4866) :701-703

[10] GLYCINE POTENTIATES THE NMDA RESPONSE IN CULTURED MOUSE-BRAIN NEURONS [J].

JOHNSON, JW ;

ASCHER, P .

NATURE, 1987, 325 (6104) :529-531