DISTRIBUTION OF ANGIOTENSIN-II RECEPTOR-BINDING IN THE SPINAL-CORD OF THE SHEEP

被引：30

作者：

OLDFIELD, BJ ^{[1
]}

ALLEN, AM ^{[1
]}

HARDS, DK ^{[1
]}

MCKINLEY, MJ ^{[1
]}

SCHLAWE, I ^{[1
]}

MENDELSOHN, FAO ^{[1
]}

机构：

[1] UNIV MELBOURNE, AUSTIN HOSP,DEPT MED, HEIDELBERG, VIC 3084, AUSTRALIA

来源：

BRAIN RESEARCH | 1994年 / 650卷 / 01期

基金：

英国医学研究理事会;

关键词：

ANGIOTENSIN BINDING; SPINAL CORD; INTERMEDIOLATERAL NUCLEUS; SYMPATHETIC NERVOUS SYSTEM; DORSAL ROOT GANGLIA; DORSAL HORN; PARASYMPATHETIC NERVOUS SYSTEM;

D O I：

10.1016/0006-8993(94)90204-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of angiotensin II binding sites has been mapped at segmental levels throughout the spinal cord of the sheep using in vitro autoradiographic methods. Binding of I-125-[Sar(1), Ile(8)] Ang II is most prominent in the lateral horns of the thoracolumbar and sacral regions containing the sympathetic and parasympathetic preganglionic neurons respectively. Binding is also present in the dorsal horns of the grey matter, in the central canal region, dorsal root ganglia and associated with non-neuronal elements such as the ependyma surrounding the central canal, and blood vessels. Displacement with receptor antagonists specific for AT(1) and AT(2) subtypes, indicates that angiotensin II receptors in the spinal cord are of the AT(1) type. These data help to interpret the physiological actions of angiotensin II in the spinal cord, particularly with respect to its autonomic components.

引用

页码：40 / 48

页数：9

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