RH-5849, A NONSTEROIDAL ECDYSONE AGONIST, DOES NOT MIMIC MAKISTERONE-A IN DYSDERCUS-KOENIGII

被引：5

作者：

KOUL, O

KAPIL, RS

机构：

[1] Regional Research Laboratory, Jammu, 180001, Canal Road

来源：

EXPERIENTIA | 1994年 / 50卷 / 05期

关键词：

DYSDERCUS KEONIGII; ECDYSONE MIMIC RH-5849; MAKISTERONE-A; JUVENILIZING EFFECT; TOXICITY;

D O I：

10.1007/BF01920747

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The response of final instar nymphs of Dysdercus koenigii to topical application of the non-steroidal ecdysone agonist, RH-5849, was dose dependent. The candidate compound produced mortality even at moderate doses, but precocious adult development was not observed. Similar results were obtained after oral administration or injection. Conversely, injections of makisterone-A (the principal moulting hormone of Dysdercus) into 5th instar nymphs resulted in precocious adult development within 4 days. We conclude that RH-5849 does not mimic makisterone-A, as is the case with ecdysone, and that toxicity is mediated instead through non-endocrine targets in this insect species.

引用

页码：461 / 464

页数：4

共 20 条

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[2]

ASHOK M, 1991, BIOCHEM INT, V24, P69

[3] DEVELOPMENTAL DISTURBANCES IN DIFFERENT INSECT ORDERS CAUSED BY AN ECDYSTEROID AGONIST, RH 5849 [J].