REGULATION OF EXTRACELLULAR ADENOSINE LEVELS IN THE STRIATUM OF AGING RATS

被引：42

作者：

PAZZAGLI, M ^{[1
]}

CORSI, C ^{[1
]}

FRATTI, S ^{[1
]}

PEDATA, F ^{[1
]}

PEPEU, G ^{[1
]}

机构：

[1] UNIV FLORENCE,DEPT PRECLIN & CLIN PHARMACOL,I-50134 FLORENCE,ITALY

来源：

BRAIN RESEARCH | 1995年 / 684卷 / 01期

关键词：

ADENOSINE; BRAIN MICRODIALYSIS; STRIATUM; AGING; N-METHYL-D-ASPARTATE RECEPTOR; ADENOSINE KINASE; ADENOSINE DEAMINASE;

D O I：

10.1016/0006-8993(95)00471-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular adenosine concentrations, evaluated by microdialysis in the striatum of young and aged rats, were 66.8 +/- 0.7 and 71.6 +/- 1.0 nM, respectively. The adenosine deaminase inhibitor EHNA (100 mu M) increased the extracellular adenosine levels in young rats only. The adenosine kinase inhibitor iodotubercidin (10 mu M) brought about the same increase in young and aged rats. In aged rats the resting adenosine outflow was reduced by the N-methyl-D-aspartate (NMDA) receptor antagonist D-(-)-2-amino-7-phophonoheptanoic acid (D-AP7) (1 mM). It is concluded that extracellular levels of adenosine in the striatum are not affected by age, irrespective of the differences in adenosine deaminase activity and that the release of excitatory amino acids is responsible for much of resting adenosine outflow in aged but not in young rats.

引用

页码：103 / 106

页数：4

共 20 条

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