THERMAL-STABILITY OF MEFRUSIDE POLYVINYLPYRROLIDONE SOLID DISPERSIONS

被引：5

作者：

JUNGINGER, HE

WEDLER, M

机构：

[1] STATE UNIV LEIDEN, GORLAEUS LABS, CTR BIOPHARMACEUT SCI, DIV PHARMACEUT TECHNOL, 2312 AV LEIDEN, NETHERLANDS

[2] TECH UNIV BRUNSWICK, INST PHARMAZEUT TECHNOL, D-3300 BRUNSWICK, FED REP GER

来源：

PHARMACEUTICAL RESEARCH | 1986年 / 3卷 / 01期

关键词：

D O I：

10.1023/A:1016320831469

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The stability of mefruside-polyvinylpyrrolidone (PVP)30 solid dispersions at ratios of mefruside/PVP 30 of 9/1, 7/3, and 5/5 (g/g) after mechanical (tableting) and allothermic stressing (50, 60, and 70.degree. C up to 240 hr) was investigated. Only the 5/5 (g/g) solid dispersion showed no recrystallization of mefruside, whereas a slight increase in crystallinity in the 7/3 (g/g) solid dispersion and a strong increase in the 9/1 (g/g) product were detected. The mechanisms of drug recrystallization in such "high-energy products" are discussed.

引用

页码：41 / 44

页数：4

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