THE THYROGLOBULIN GENE - EVOLUTIONARY AND REGULATORY ISSUES

被引：16

作者：

CHRISTOPHE, D ^{[1
]}

VASSART, G ^{[1
]}

机构：

[1] HOP ERASME,SERV GENET MED,B-1070 BRUSSELS,BELGIUM

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1990年 / 1卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/1043-2760(90)90083-F

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The coding information for thyroglobulin synthesis is contained in a large transcription unit, which is made from the juxtaposition of short repetitive gene modules and of a copy of an ancient acetylcholinesterase homologue. Minor alternatively spliced transcripts with conservation of the reading frame seem to be common. Whether they have a role or represent noise in the splicing phenomena is unknown. Transcription of the thyroglobulin gene is controlled by cAMP through a pathway involving sequence motifs and trans-acting factors that differ from those identified so far in other systems. © 1990.

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收藏

页码：351 / 356

页数：6

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