INHIBITION OF RAT-BRAIN MONOAMINE-OXIDASE ACTIVITY BY CEREBRAL ANTIISCHEMIC AGENT, IFENPRODIL

被引：7

作者：

ARAI, Y

NAKAZATO, K

KINEMUCHI, H

TADANO, T

SATOH, N

OYAMA, K

KISARA, K

机构：

[1] GRELEN PHARMACEUT CO LTD,SETAGAYA KU,TOKYO 154,JAPAN

[2] ISHINOMAKI SENSHU UNIV,FAC SCI & ENGN,BIOL CHEM LAB,ISHINOMAKI 986,JAPAN

[3] TOHOKU COLL PHARMACEUT SCI,DEPT PHARMACOL,AOBA KU,SENDAI 981,JAPAN

来源：

NEUROPHARMACOLOGY | 1991年 / 30卷 / 07期

关键词：

MONOAMINE OXIDASE (MAO); MAO-A; MAO-B; INHIBITION OF MAO; IFENPRODIL; ANTIISCHEMIC EFFECT;

D O I：

10.1016/0028-3908(91)90190-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ifenprodil, which is clinically used as a cerebral vasodilator, inhibited rat brain type A (MAO-A) and type B (MAO-B) monoamine oxidase activity. It did not, however, affect rat lung semicarbazide-sensitive amine oxidase. The degree of inhibition of either form of MAO vas not changed by 30 min preincubation of the enzyme preparations at 37-degrees-C with ifenprodil. Modes of inhibition of MAO-A and MAO-B by ifenprodil were competitive towards oxidation of their respective substrates, S-hydroxytryptamine and benzylamine, with Ki values of 75-mu-M for inhibition of MAO-A and 110-mu-M for inhibition of MAO-B.

引用

页码：809 / 812

页数：4

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