SYNTHESIS AND EVALUATION OF NEW PROTEIN-TYROSINE KINASE INHIBITORS .1. PYRIDINE-CONTAINING STILBENES AND AMIDES

被引:16
作者
CUSHMAN, M
NAGARATHNAM, D
GOPAL, D
GEAHLEN, RL
机构
[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette
关键词
D O I
10.1016/S0960-894X(00)80254-1
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of pyridine-containing stilbene and amide derivatives based on the structure of piceatannol, a naturally occurring protein-tyrosine kinase inhibitor, has been prepared and tested for inhibition of p56lck. The most potent of these compounds is a competitive inhibitor of p56lck with respect to ATP.
引用
收藏
页码:211 / 214
页数:4
相关论文
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