SYNTHESIS AND EVALUATION OF NEW PROTEIN-TYROSINE KINASE INHIBITORS .1. PYRIDINE-CONTAINING STILBENES AND AMIDES

被引：16

作者：

CUSHMAN, M

NAGARATHNAM, D

GOPAL, D

GEAHLEN, RL

机构：

[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)80254-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of pyridine-containing stilbene and amide derivatives based on the structure of piceatannol, a naturally occurring protein-tyrosine kinase inhibitor, has been prepared and tested for inhibition of p56lck. The most potent of these compounds is a competitive inhibitor of p56lck with respect to ATP.

引用

页码：211 / 214

页数：4

共 27 条

[1]

AKIYAMA T, 1987, J BIOL CHEM, V262, P5592

[2] ELECTROCHEMICAL REACTIONS .14. CARBON-HALOGEN BOND FRAGMENTATION IN RADICAL-ANIONS FROM 4-(CHLOROSTYRYL)PYRIDINES - FACTORS WHICH DETERMINE RATE OF SUCH FRAGMENTATIONS [J].

ALWAIR, K ;

GRIMSHAW, J .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1973, (08) :1150-1154

[3]

BAKER BR, 1971, J MED CHEM, V14, P1057

[4]

CARPENTER G, 1987, ANNU REV BIOCHEM, V56, P881, DOI 10.1146/annurev.bi.56.070187.004313

[5] ACTIVATION OF THE PP60C-SRC PROTEIN-KINASE IS AN EARLY EVENT IN COLONIC CARCINOGENESIS [J].

CARTWRIGHT, CA ;

MEISLER, AI ;

ECKHART, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :558-562

[6] SYNTHESIS AND PROTEIN-TYROSINE KINASE INHIBITORY ACTIVITIES OF FLAVONOID ANALOGS [J].

CUSHMAN, M ;

NAGARATHNAM, D ;

BURG, DL ;

GEAHLEN, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) :798-806

[7] HETEROCYCLIC ANALOGUES OF PINOSYLVIN [J].

ERDTMAN, H ;

ROSENGREN, A .

ACTA CHEMICA SCANDINAVICA, 1968, 22 (05) :1475-+

[8]

ERNEUX C, 1983, J BIOL CHEM, V258, P4137

[9] TYRPHOSTINS .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF PROTEIN TYROSINE KINASE INHIBITORS [J].

GAZIT, A ;

YAISH, P ;

GILON, C ;

LEVITZKI, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (10) :2344-2352

[10] PICEATANNOL (3,4,3',5'-TETRAHYDROXY-TRANS-STILBENE) IS A NATURALLY-OCCURRING PROTEIN-TYROSINE KINASE INHIBITOR [J].

GEAHLEN, RL ;

MCLAUGHLIN, JL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) :241-245

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