APPLICATIONS OF CELLULOSE-BASED CHIRAL STATIONARY PHASES IN THE RESOLUTION OF SOME BETA-ADRENOCEPTOR ANTAGONISTS

Cellulose tris (3,5-dimethylphenyl carbamate) known as Chiralcel OD chiral stationary phase (CSP) is one of the most commonly used cellulosic CSPs which have been successfully used for separation, enantiomeric purity determination and analysis of several drug racemates including beta-adrenoceptor antagonists. Resolution of timolol, penbutolol, celiprolol and carazolol enantiomers are achieved using this CSP. A possible chiral recognition mechanism(s) for these beta-adrenergic blockers and this chiral stationary phase is presented.