A SPIN LABEL STUDY OF THE ACTION OF CUPRIC AND MERCURIC IONS ON HUMAN RED-BLOOD-CELLS

被引：24

作者：

GWOZDZINSKI, K

机构：

[1] Department of Biophysics, University of Lód

来源：

TOXICOLOGY | 1991年 / 65卷 / 03期

关键词：

COPPER; MERCURY; ERYTHROCYTE; SPIN LABELS;

D O I：

10.1016/0300-483X(91)90090-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of heavy metal ions on human red blood cells was studied. Electron spin resonance studies of human erythrocytes labelled either with methyl 5-doxylpalmitate or methyl 12-doxylstearate indicated that cupric and mercuric ions increase the rigidity of membrane lipid bilayers. Both metals also induce conformational changes of membrane proteins and modify cell internal peptides and proteins as indicated by a 4-maleimido-2,2,6,6-tetramethylpiperidine-1-oxyl label ESR study. Copper and mercury ions decreased internal viscosity of red blood cells.

引用

收藏

页码：315 / 323

页数：9

相关论文

共 32 条

[1] STUDIES OF THE MOBILITY OF MALEIMIDE SPIN LABELS WITHIN THE ERYTHROCYTE-MEMBRANE [J].

BARBER, MJ ;

ROSEN, GM ;

RAUCKMAN, EJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 732 (01) :126-132

[2] THE SPIN-LABEL APPROACH TO LABELING MEMBRANE-PROTEIN SULFHYDRYL-GROUPS [J].

BERLINER, LJ .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1983, 414 (DEC) :153-161

[3] DIFFERENTIAL EFFECT OF LIPID-PEROXIDATION ON MEMBRANE FLUIDITY AS DETERMINED BY ELECTRON-SPIN RESONANCE PROBES [J].

BRUCH, RC ;

THAYER, WS .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 733 (02) :216-222

[4] ELECTRON-SPIN RESONANCE STUDIES OF MEMBRANE PROTEINS IN ERYTHROCYTES IN MYOTONIC MUSCULAR-DYSTROPHY [J].

BUTTERFIELD, DA ;

ROSES, AD ;

APPEL, SH ;

CHESNUT, DB .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1976, 177 (01) :226-234

[5] COPPER(II)-CATALYZED LIPID-PEROXIDATION IN LIPOSOMES AND ERYTHROCYTE-MEMBRANES [J].

CHAN, PC ;

PELLER, OG ;

KESNER, L .

LIPIDS, 1982, 17 (05) :331-337

[6] SINGLET OXYGEN IN COPPER-CATALYZED LIPID-PEROXIDATION IN ERYTHROCYTE-MEMBRANES [J].

DING, AH ;

CHAN, PC .

LIPIDS, 1984, 19 (04) :278-284

[7]

FUJIMOTO Y, 1984, RES COMMUN CHEM PATH, V44, P495

[8]

GABRYELAK T, 1987, STUD KIELECKIE, V4, P109

[9]

Gaffney B.J., 1976, SPIN LABELING THEORY, P183

[10] EFFECT OF THIOL REAGENTS AND IONIZING-RADIATION ON THE PERMEABILITY OF ERYTHROCYTE-MEMBRANE FOR SPIN-LABELED NON-ELECTROLYTES [J].

GWOZDZINSKI, K ;

BARTOSZ, G ;

LEYKO, W .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1983, 22 (01) :53-59

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