CYTOGENETIC FINDINGS AND SURVIVAL IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA - 2ND IWCCLL COMPILATION OF DATA ON 662 PATIENTS

被引：90

作者：

JULIUSSON, G

GAHRTON, G

OSCIER, D

FITCHETT, M

ROSS, F

BRITOBABAPULLE, V

CATOVSKY, D

KNUUTILA, S

ELONEN, E

LECHLEITNER, M

TANZER, J

SCHOENWALD, M

CASTOLDI, GL

CUNEO, A

NOWELL, P

PETERSON, L

KAY, N

机构：

[1] Gösta Gahrton for the International Working Party on Chromosomes in CLL (IWCCLL), Huddinge

[2] The Division of Clinical Hematology and Oncology, Department of Medicine, Karolinska Institute at Huddinge Hospital, Huddinge

来源：

LEUKEMIA & LYMPHOMA | 1991年 / 5卷

关键词：

CYTOGENETIC FINDINGS; SURVIVAL; CLL;

D O I：

10.3109/10428199109103374

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chromosome analysis on CLL-cells from 649 patients revealed clonal changes in 311 cases (48% The most common abnormalities were trisomy 12 (n = 112), and structural changes on the long arm of chromosome 13 (n = 62), most of them interstitial deletions or translocations involving 13q14, the site of the retinoblastoma gene. Complex karyotypes were associated with poor prognosis, although karyotypic changes rarely develop during the course of the disease. Among patients with single chromosomal abnormalities those with trisomy 12 had a poor survival, whereas those with structural changes on chromosome 13 had as good a prognosis as patients with a normal karyotype. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：21 / 25

页数：5

共 31 条

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