BORIC-ACID EFFECT ON THE HYDROLYSIS OF 4-NITROPHENYL 2,3-DIHYDROXYBENZOATE - MIMIC OF BORATE INHIBITION OF SERINE PROTEASES

被引：8

作者：

YATSIMIRSKY, AK

BEZSOUDNOVA, KY

SAKODINSKAYA, IK

机构：

[1] Department of Chemistry, Moscow State University

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81244-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Boric acid inhibits the hydrolysis of deprotonated 4-nitrophenyl 2,3-dihydroxybenzoate which proceeds with intramolecular general base assistance. This effect is opposite to previously reported borate catalysis of the hydrolysis of salycilic acid esters and mimics borate inhibition of serine proteases.

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页码：635 / 638

页数：4

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