USE OF IN-VITRO METHODOLOGY TO PREDICT THE IRRITANCY POTENTIAL OF SURFACTANTS

被引：18

作者：

HUBBARD, AW ^{[1
]}

MOORE, LJ ^{[1
]}

CLOTHIER, RH ^{[1
]}

SULLEY, H ^{[1
]}

ROLLIN, KA ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT HUMAN MORPHOL,FRAME ALTERNAT LAB,NOTTINGHAM NG7 2UH,ENGLAND

来源：

TOXICOLOGY IN VITRO | 1994年 / 8卷 / 04期

关键词：

D O I：

10.1016/0887-2333(94)90044-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A battery of confirmatory and complementary in vitro assays was used to investigate a series of surfactants with different irritancy potentials, as confirmed by human skin patch testing. This was found to distinguish between sodium lauryl sulfate and its analogues, and when further tested on formulations the battery of assays was again capable of predicting the human data.

引用

页码：689 / 691

页数：3

共 10 条

[1]

BALLS M, 1992, IN VITRO METHODS TOX, P37

[2] THE LUMINESCENT BACTERIA TOXICITY TEST - ITS POTENTIAL AS AN INVITRO ALTERNATIVE [J].

BULICH, AA ;

TUNG, KK ;

SCHEIBNER, G .

JOURNAL OF BIOLUMINESCENCE AND CHEMILUMINESCENCE, 1990, 5 (02) :71-77

[3] DEVELOPMENT OF A FIXED-DOSE APPROACH FOR THE FLUORESCEIN LEAKAGE TEST [J].

CLOTHIER, RH ;

MORGAN, SJ ;

ATKINSON, KA ;

GARLE, MJ ;

BALLS, M .

TOXICOLOGY IN VITRO, 1994, 8 (04) :883-884

[4]

GORDON VC, 1992, ATLA-ALTERN LAB ANIM, V20, P537

[5]

HUBBARD AE, 1991, IN HOUSE DEV DEP PRO

[6]

MARTIN CG, 1993, ATLA-ALTERN LAB ANIM, V21, P239

[7]

SHAW AJ, 1990, ATLA-ALTERN LAB ANIM, V18, P145

[8]

1991, ZEIN TEST ERGATT FRA

[9]

1990, FRAME NEUTRAL RED RE

[10]

1990, FRAME CYTOTOXICITY T

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