PHARMACOLOGY OF 2 NEW VERY SELECTIVE ANTIPROGESTAGENS - ORG-31710 AND ORG-31806

被引：40

作者：

KLOOSTERBOER, HJ ^{[1
]}

DECKERS, GH ^{[1
]}

SCHOONEN, WGEJ ^{[1
]}

机构：

[1] ORGANON INT BV,DEPT ENDOCRINOL,OSS,NETHERLANDS

来源：

HUMAN REPRODUCTION | 1994年 / 9卷

关键词：

ANTIPROGESTAGENS; BREAST TUMORS; FERTILITY CONTROL; ORG; 31710; 31806; RU486; ZK98299;

D O I：

10.1093/humrep/9.suppl_1.47

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Org 31710 and Org 31806 are new antiprogestagens. These compounds were tested for their binding affinity to various steroid receptors and for their bio-activity in various animal models and the results were compared with those of RU38486 and ZK 98299. Both Org compounds are strong antiprogestagens with little antiglucocortocoid activity and are devoid of other hormonal activities except for some weak androgenic and anti-androgenic activity. The two compounds are more potent than RU38486 and ZK 98299 with respect to their anti-progestational activity and are more selective. The Org compounds are effective in inhibiting the development of tumours in the 7,12-dimethylbenz(a)anthracene (DMBA) rat model. Org 31710 and Org 31806 may be applied for both the treatment of breast tumours and the improvement of fertility control.

引用

页码：47 / 52

页数：6

共 20 条

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