A STRIKING HOMOLOGY BETWEEN CFTR AND ANNEXINS

被引：17

作者：

CHAP, H

FAUVEL, J

GASSAMADIAGNE, A

RAGABTHOMAS, J

SIMON, MF

机构：

来源：

M S-MEDECINE SCIENCES | 1991年 / 7卷 / 01期

关键词：

D O I：

10.4267/10608/4270

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A significant homology (47-37 %) has been observed between subsequence 500-529 of CFTR (cystic fibrosis transmembrane conductance regulator) and 8 different annexins. This segment includes the functionnally very critical phenylalanine 508 residue, which is fully conserved among annexins. This suggests some possible common interactions of CFTR and annexins with other yet unidentified cell components present in or close to the submembraneous space.

引用

页码：8 / 9

页数：2