A NOVEL ANTIFUNGAL ANTIBIOTIC, FR-900848 .1. PRODUCTION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：108

作者：

YOSHIDA, M

EZAKI, M

HASHIMOTO, M

YAMASHITA, M

SHIGEMATSU, N

OKUHARA, M

KOHSAKA, M

HORIKOSHI, K

机构：

[1] FUJISAWA PHARMACEUT CO LTD,EXPLORATORY RES LABS,TSUKUBA,IBARAKI 30026,JAPAN

[2] TOKYO INST TECHNOL,DEPT BIOENGN,TOKYO 152,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 07期

关键词：

D O I：

10.7164/antibiotics.43.748

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C32H43N3O6, which consists of 5′-amino-5′-deoxy-5,6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cyclopropane rings. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：748 / 754

页数：7

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