EPIDEMIOLOGIC INVESTIGATION OF THE ASSOCIATION BETWEEN INFECTIOUS-MONONUCLEOSIS AND MULTIPLE-SCLEROSIS

被引：74

作者：

LINDBERG, C

ANDERSEN, O

VAHLNE, A

DALTON, M

RUNMARKER, B

机构：

[1] GOTHENBURG UNIV,DEPT NEUROL,S-41124 GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT VIROL,S-41124 GOTHENBURG,SWEDEN

来源：

NEUROEPIDEMIOLOGY | 1991年 / 10卷 / 02期

关键词：

MULTIPLE SCLEROSIS; INFECTIOUS MONONUCLEOSIS; RISK FACTOR;

D O I：

10.1159/000110248

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

By matching a cohort of 494 infectious mononucleosis (IM) cases with a multiple sclerosis (MS) register, 3 MS cases were retrieved. The interval between IM and MS was 12 years. This corresponds to a relative risk of 3.7 for MS to occur subsequent to IM (p = 0.05). This relationship between a manifestation of a relatively late Epstein-Barr virus infection and MS may indicate that a microbiologically shielded environment is important in the pathogenesis of MS.

引用

页码：62 / 65

页数：4

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