ALCOHOL CAN INHIBIT EFFECT OF IL-4 ON ACTIVATED MURINE B-CELLS

被引：13

作者：

ALDOBENSON, M

PRATT, L

HARDWICK, J

机构：

[1] Division of Rheumatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202-5103, IN, 541 Clinical Drive

来源：

IMMUNOLOGIC RESEARCH | 1992年 / 11卷 / 02期

关键词：

ETHANOL; IL-4; LYMPHOCYTE-B PROLIFERATION;

D O I：

10.1007/BF02918616

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ethanol addition to B lymphocytes in vitro inhibits antigen-induced antibody secretion and antigen-induced cell proliferation. We tested the hypothesis that ethanol can inhibit the effect of interleukins on B-cell proliferation by adding ethanol to in vitro functional assays for IL-2 and IL-4. Ethanol does not inhibit IL-2-induced B-cell differentiation, but it does inhibit IL-4-induced B-cell proliferation and IL-4-induced Ig class switching.

引用

页码：117 / 124

页数：8

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