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CONCORDANCE OF TESTS TO DETECT ANTIBODIES TO HEPATITIS-C VIRUS
被引：5
作者：
CONSTANTINE, NT
CALLAHAN, JD
BANSAL, J
ZHANG, X
HYAMS, KC
机构：
[1] Department of Pathology, Univ. of Maryland School of Medicine, Baltimore, MD 21201
关键词：
D O I：
10.1093/labmed/23.12.807
中图分类号：
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
A large variety of new assays are available to test for antibodies to hepatitis C virus. We investigated the concordance of two FDA-licensed screening assays and determined their specificities in relation to two supplemental tests, Abbott's neutralization assay and Ortho's second generation RIBA-2. Of 573 serum samples from individuals at high risk for sexually transmitted diseases, 81 (14.1%) were repeatedly reactive by both screening tests and produced positive results by both supplemental assays, while 480 (83.8%) samples were nonreactive. Ten of the positive samples were reactive by the RIBA-2 assay to at least two antigens other than c100-3, and were neutralized (88% to 100%) by Abbott's supplemental assay. Twelve samples produced discrepant results, including one false-negative and 10 false-positive screening test results.
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页码：807 / 810
页数：4
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