THIOL AND HYDROXAMIC ACID-CONTAINING INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME

被引：12

作者：

BERTENSHAW, SR ^{[1
]}

TALLEY, JJ ^{[1
]}

ROGERS, RS ^{[1
]}

CARTER, JS ^{[1
]}

MOORE, WM ^{[1
]}

BRANSON, LM ^{[1
]}

KOBOLDT, CM ^{[1
]}

机构：

[1] MONSANTO CORP RES,MOLEC PHARMACOL,ST LOUIS,MO 63167

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)80994-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A group of peptido-mimetic molecules containing either a thiol or hydroxamic acid moiety were synthesized and evaluated for in vitro inhibition of a putative endothelin converting enzyme (ECE) partially purified from rabbit lung membranes. These compounds were envisioned as analogs of the phosphoramide containing metalloprotease inhibitor phosphoramidon.

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页码：1953 / 1958

页数：6

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