ASYMMETRIC-SYNTHESIS OF ALPHA-SUBSTITUTED BETA-AMINO ACIDS USING A BETA-ALANINE DERIVATIVE WITH 2 CHIRAL HANDLES

被引：7

作者：

AKSSIRA, M

BOUMZEBRA, M

KASMI, H

ROUMESTANT, ML

VIALLEFONT, P

机构：

[1] UNIV MONTPELLIER 2,CNRS,URA 468,F-34095 MONTPELLIER 5,FRANCE

[2] UNIV ABDELMALEK ESSAADI,FAC SCI,CHIM ORGAN LAB,TETOUAN,MOROCCO

来源：

AMINO ACIDS | 1994年 / 7卷 / 01期

关键词：

AMINO ACIDS; BETA-AMINO ACID; ASYMMETRIC SYNTHESIS; SCHIFF BASE; 2-HYDROXYPINAN-3-ONE; MENTHOL;

D O I：

10.1007/BF00808448

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomerically pure alpha-substituted beta-amino acids have been synthesized, the key step being the diastereoselective alkylation of a beta-alanine derivative with two chiral handles (1S,2R,5S)-menthyl N-[(1S,2S,5S)-2-hydroxypinan-3-ylidene] beta-alaninate.

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收藏

页码：79 / 81

页数：3

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