MODELING THE EFFECT OF TREATMENT AND BEHAVIORAL-CHANGE IN HIV TRANSMISSION DYNAMICS

被引:48
作者
VELASCOHERNANDEZ, JX
HSIEH, YH
机构
[1] UNIV AUTONOMA METROPOLITANA XOCHIMILCO, DEPT EL HOMBRE & AMBIENTE, MEXICO CITY, DF, MEXICO
[2] NATL CHUNGHSING UNIV, DEPT APPL MATH, TAICHUNG, TAIWAN
关键词
EPIDEMIOLOGIC MODELS; HIV TRANSMISSION; BOUNDED POPULATION SIZE; TREATMENT AND BEHAVIORAL CHANGE THRESHOLD; GLOBAL STABILITY; NONEXISTENCE OF PERIODIC SOLUTIONS;
D O I
10.1007/BF00163880
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this paper we analyze a model for the HIV-infection transmission in a male homosexual population. In the model we consider two types of infected individuals. Those that are infected but do not know their serological status and/or are not under any sort of clinical/therapeutical treatment, and those who are. The two groups of infectives differ in their incubation time, contact rate with susceptible individuals, and probability of disease transmission. The aim of this article is to study the roles played by detection and changes in sexual behavior in the incidence and prevalence of HIV. The analytical results show that there exists a unique endemic equilibrium which is globally asymptotically stable under a range of parameter values whenever a detection/treatment rate and an indirect measure of the level of infection risk are sufficiently large. However, any level of detection/treatment rate coupled with a decrease of the transmission probability lowers the incidence rate and prevalence level in the population. In general, only significant reductions in the transmission probability (achieved through, for example, the adoption of safe sexual practices) can contain effectively the spread of the disease.
引用
收藏
页码:233 / 249
页数:17
相关论文
共 24 条
[1]  
ANDERSON R M, 1991
[2]   POTENTIAL OF COMMUNITY-WIDE CHEMOTHERAPY OR IMMUNOTHERAPY TO CONTROL THE SPREAD OF HIV-1 [J].
ANDERSON, RM ;
GUPTA, S ;
MAY, RM .
NATURE, 1991, 350 (6316) :356-359
[3]   AIDS AND BEHAVIORAL-CHANGE TO REDUCE RISK - A REVIEW [J].
BECKER, MH ;
JOSEPH, JG .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1988, 78 (04) :394-410
[4]  
BLYTHE SP, 1989, LECT NOTES BIOMATH, V83, P275
[5]  
BLYTHE SP, 1991, AUTONOMOUS RISK BEHA
[6]  
BRAUER F, 1992, BU1154M BIOM UN TECH
[7]  
BUEHLER JW, 1992, J ACQ IMMUN DEF SYND, V5, P257
[8]   ANALYSIS OF A DISEASE TRANSMISSION MODEL IN A POPULATION WITH VARYING SIZE [J].
BUSENBERG, S ;
VANDENDRIESSCHE, P .
JOURNAL OF MATHEMATICAL BIOLOGY, 1990, 28 (03) :257-270
[9]   A GENERAL-SOLUTION OF THE PROBLEM OF MIXING OF SUBPOPULATIONS AND ITS APPLICATION TO RISK-STRUCTURED AND AGE-STRUCTURED EPIDEMIC MODELS FOR THE SPREAD OF AIDS [J].
BUSENBERG, S ;
CASTILLOCHAVEZ, C .
IMA JOURNAL OF MATHEMATICS APPLIED IN MEDICINE AND BIOLOGY, 1991, 8 (01) :1-29
[10]  
GAIL MH, 1990, J ACQ IMMUN DEF SYND, V3, P296