INHIBITION OF A 5-HT3 RECEPTOR-MEDIATED CURRENT BY THE SELECTIVE SEROTONIN UPTAKE INHIBITOR, FLUOXETINE

被引：38

作者：

FAN, P

机构：

[1] Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852

来源：

NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期

关键词：

5-HT3; RECEPTOR; PATCH CLAMP; NODOSE GANGLION NEURON; FLUOXETINE; ANTIDEPRESSANT; SEROTONIN UPTAKE INHIBITOR;

D O I：

10.1016/0304-3940(94)90185-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the selective serotonin uptake inhibitor, fluoxetine, on the inward current mediated by 5-HT3 receptors was investigated with the whole-cell patch-clamp technique. Fluoxetine inhibited the peak 5-HT current with an IC50 value of 1.2 mu M. During continuous application of fluoxetine at concentrations of less than or equal to 1 mu M, there was a transient decrease in the fluoxetine-induced inhibition of 5-HT current. It is suggested that fluoxetine may have a short-lived action on 5-HT current and that the 5-HT3 receptor is a possible acting site for the therapeutic use of fluoxetine.

引用

页码：210 / 212

页数：3

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