ENANTIOSELECTIVE DARZENS REACTION - ASYMMETRIC-SYNTHESIS OF TRANS-GLYCIDIC ESTERS MEDIATED BY CHIRAL LITHIUM AMIDES

被引：28

作者：

TAKAHASHI, T ^{[1
]}

MURAOKA, M ^{[1
]}

CAPO, M ^{[1
]}

KOGA, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 10期

关键词：

ENANTIOSELECTIVE REACTION; DIASTEREOSELECTIVE REACTION; ASYMMETRIC DARZENS REACTION; CHIRAL LITHIUM AMIDE; TRANS-GLYCIDIC ESTER;

D O I：

10.1248/cpb.43.1821

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Enantioselective and diastereoselective Darzens reaction mediated by chiral lithium amides was achieved between tert-butyl chloroacetate and aromatic aldehydes to give the corresponding trans-glycidic esters in up to 84% enantiomeric excess.

引用

页码：1821 / 1823

页数：3

共 25 条

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