DECREASE IN CEREBELLIN AND CORTICOTROPIN-RELEASING HORMONE IN THE CEREBELLUM OF OLIVOPONTOCEREBELLAR ATROPHY AND SHY-DRAGER SYNDROME

被引：14

作者：

MIZUNO, Y

TAKAHASHI, K

TOTSUNE, K

OHNEDA, M

KONNO, H

MURAKAMI, O

SATOH, F

SONE, M

TAKASE, S

ITOYAMA, Y

MOURI, T

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROL,SENDAI,MIYAGI 980,JAPAN

[2] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 2,SENDAI,MIYAGI 980,JAPAN

[3] TOHOKU UNIV,SCH MED,DEPT PATHOL 2,SENDAI,MIYAGI 980,JAPAN

[4] KONANN HOSP,SENDAI,MIYAGI 980,JAPAN

来源：

BRAIN RESEARCH | 1995年 / 686卷 / 01期

关键词：

CEREBELLIN; CORTICOTROPIN-RELEASING HORMONE; OLIVOPONTOCEREBELLAR ATROPHY; SHY-DRAGER SYNDROME; NEUROPEPTIDE; CEREBELLUM; MULTIPLE SYSTEM ATROPHY; RADIOIMMUNOASSAY;

D O I：

10.1016/0006-8993(95)00467-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Four neuropeptides; cerebellin, corticotropin-releasing hormone (CRH), neuropeptide Y and somatostatin were studied by radioimmunoassay in the postmortem human brains obtained from three patients with olivopontocerebellar atrophy (OPCA) and one with Shy-Drager syndrome. Significant decreases in cerebellin and CRH concentrations were found in the cerebellar hemisphere of these diseases compared with controls. These findings suggest important pathophysiological roles of cerebellin and CRH in these cerebellar diseases. Such significant decreases were not found in neuropeptide Y and somatostatin.

引用

收藏

页码：115 / 118

页数：4

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