INHIBITION OF NITRIC-OXIDE SYNTHASE REDUCES SEPHADEX-INDUCED EDEMA FORMATION IN THE RAT LUNG - DEPENDENCE ON INTACT ADRENAL-FUNCTION

被引:15
作者
ANDERSSON, SE
KALLSTROM, L
MALM, M
MILLERLARSSON, A
AXELSSON, B
机构
[1] Dept. of Pharmacology, Astra-Draco AB, Lund, S-221 00
关键词
CORTICOSTERONE; LEUKOCYTE EMIGRATION; LUNG EDEMA; NITRIC OXIDE SYNTHASE; SEPHADEX;
D O I
10.1007/BF01757698
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the present study we have investigated the effect of L-nitro arginine mono methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthase on Sephadex induced inflammation in the rat lung. Instillation of Sephadex into the airways induced an inflammatory reaction characterized by a long-lasting interstitial oedema, measured as an increase in lung weight, and an influx of inflammatory cells into the airways. L-NAME given s.c. prevented the increase in lung weight following Sephadex instillation. The inactive enantiomer D-NAME had no effect, nor did aminoguanidine which indicates that this effect of L-NAME was mediated by inhibition of the constitutive form of NOS. Treatment with L-NAME did not reduce an established oedema. In contrast, L-NAME tended to enhance the influx of oesinophils into the airways of Sephadex-instilled animals. L-NAME did not have any effect on the development of oedema in adrenalectomized rats or in animals where formation of glucocorticosteroids (GCS) was inhibited with metyrapone. L-NAME did not however, increase plasma levels of corticosterone. The present results indicate that, in this model, inhibition of NO-synthesis has marked anti-inflammatory effects. The underlying mechanism is complex but seems not to involve prevention of overproduction of NO.
引用
收藏
页码:418 / 422
页数:5
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