2,4,5-TRIARYLIMIDAZOLE INHIBITORS OF IL-1 BIOSYNTHESIS

被引：135

作者：

GALLAGHER, TF

FIERTHOMPSON, SM

GARIGIPATI, RS

SORENSON, ME

SMIETANA, JM

LEE, D

BENDER, PE

LEE, JC

LAYDON, JT

GRISWOLD, DE

CHABOTFLETCHER, MC

BRETON, JJ

ADAMS, JL

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT CELLULAR BIOCHEM,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHARMACOL,KING OF PRUSSIA,PA 19406

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 11期

关键词：

D O I：

10.1016/0960-894X(95)00189-Z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of an effort to define the pharmacophore and discover the mechanism by which the anti-inflammatory dual cyclooxygenase / 5-lipoxygenase inhibitors SK & F 86002 and SK & F 105809 inhibit IL-1 biosynthesis, a series of substituted 2,4,5-triarylimidazole derivatives were prepared and evaluated as inhibitors of IL-1 and 5-lipoxygenase biosynthesis.

引用

页码：1171 / 1176

页数：6

共 26 条

[1] USE OF A CONTINUOUS ASSAY OF OXYGEN-CONSUMPTION TO EVALUATE THE PHARMACOLOGY OF 5-LIPOXYGENASE INHIBITORS [J].