ESTROGEN RECEPTORS AND BLOOD HORMONE LEVELS IN CERVICAL-CARCINOMA AND OTHER GYNECOLOGICAL TUMORS

被引：40

作者：

HAHNEL, R ^{[1
]}

MARTIN, JD ^{[1
]}

MASTERS, AM ^{[1
]}

RATAJCZAK, T ^{[1
]}

TWADDLE, E ^{[1
]}

机构：

[1] KING EDWARD MEM HOSP WOMEN, DIV ENDOCRINOL, SUBIACO 6008, W AUSTRALIA, AUSTRALIA

来源：

GYNECOLOGIC ONCOLOGY | 1979年 / 8卷 / 02期

关键词：

D O I：

10.1016/0090-8258(79)90029-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogen receptors were determined in the cytosols of 49 cases of cervical cancer and 15 other gynecological tumors (including ovarian cancer, vaginal cancer, and mesodermal mixed tumor of uterus and polyps). The DNA content of the cervical tissues and the protein content of their cytosols were also measured. The concentration in the plasma of estradiol, estrone, testosterone, sex hormone binding globulin, and FSH was determined at the same time. The proportion of estrogen-receptor positive tumors was greater in adenocarcinomas of the cervix than in squamous carcinomas of the cervix. The mean DNA content of estrogen-receptor positive cervical carcinoma was higher than that of estrogen-receptor negative carcinomas. Testosterone levels in plasma of premenopausal women with cervical cancer were significantly lower than in controls. © 1979.

引用

页码：226 / 233

页数：8

共 11 条

[1]

ABRAHAM GE, 1975, OBSTET GYNECOL, V45, P271

[2] CONCENTRATION OF UNCONJUGATED ESTRONE AND ESTRADIOL IN PERIPHERAL PLASMA IN NONPREGNANT WOMEN THROUGHOUT MENSTRUAL CYCLE CASTRATE AND POSTMENOPAUSAL WOMEN AND IN MEN [J].

BAIRD, DT ;

GUEVARA, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1969, 29 (02) :149-+

[3] SEX-HORMONE-BINDING GLOBULIN IS AN ESTROGEN AMPLIFIER [J].

BURKE, CW ;

ANDERSON, DC .

NATURE, 1972, 240 (5375) :38-+

[4]

DRILL VA, 1976, J TOXICOL ENV HEALTH, P193

[5] ESTROGEN RECEPTORS AND BLOOD HORMONE LEVELS IN ENDOMETRIAL CARCINOMA [J].

HAHNEL, R ;

MARTIN, JD ;

MASTERS, AM ;

RATAJCZAK, T ;

TWADDLE, E .

GYNECOLOGIC ONCOLOGY, 1979, 8 (02) :209-225

[6] ESTROGEN RECEPTORS IN HUMAN BREAST-CANCER .2. IN-VITRO BINDING OF ESTRADIOL BY BENIGN AND MALIGNANT TUMORS [J].

HAHNEL, R ;

TWADDLE, E ;

VIVIAN, AB .

STEROIDS, 1971, 18 (06) :681-&

[7] RADIOIMMUNOASSAY OF TESTOSTERONE WITHOUT CHROMATOGRAPHY [J].

ISMAIL, AA ;

MIDGLEY, AR ;

NISWENDER, GD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 34 (01) :177-+

[8] PLASMA-LEVELS OF ESTROGENS, ANDROGENS AND PROGESTERONE DURING NORMAL AND DEXAMETHASONE-TREATED CYCLES [J].

KIM, MH ;

HOSSEINIAN, AH ;

DUPON, C .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1974, 39 (04) :706-712

[9] A RADIO-LIGAND BINDING ASSAY SYSTEM FOR ESTRADIOL MEASUREMENT IN HUMAN PLASMA [J].

KORENMAN, SG ;

PERRIN, LE ;

MCCALLUM, TP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1969, 29 (07) :879-+

[10] SPECIFIC ESTROGEN BINDING-PROTEINS IN HUMAN CERVIX [J].

SANBORN, BM ;

HELD, B ;

KUO, HS .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1975, 6 (07) :1107-1112

← 1 2 →