EVIDENCE FOR COENZYME-Q FUNCTION IN TRANSPLASMA MEMBRANE ELECTRON-TRANSPORT

被引：27

作者：

SUN, IL ^{[1
]}

SUN, EE ^{[1
]}

CRANE, FL ^{[1
]}

MORRE, DJ ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT MEDICINAL CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91542-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transplasma membrane electron transport activity has been associated with stimulation of cell growth. Coenzyme Q is present in plasma membranes and because of its lipid solubility would be a logical carrier to transport electrons across the plasma membrane. Extraction of coenzyme Q from isolated rat liver plasma membranes decreases the NADH ferricyanide reductase and added coenzyme Q10 restores the activity. Piericidin and other analogs of coenzyme Q inhibit transplasma membrane electron transport as measured by ferricyanide reduction by intact cells and NADH ferricyanide reduction by isolated plasma membranes. The inhibition by the analogs is reversed by added coenzyme Q10. Thus, coenzyme Q in plasma membranes may act as a transmembrane electron carrier for the redox system which has been shown to control cell growth. © 1990.

引用

页码：979 / 984

页数：6

共 25 条

[1] COENZYME-Q .133. EFFECT OF HYDROXY ANALOGS OF COENZYME Q ON DPNH-OXIDASE AND SUCCIN-OXIDASE ACTIVITIES OF YEAST MITOCHONDRIA [J].

CASTELLI, A ;

BERTOLI, E ;

LITTARRU, GP ;

LENAZ, G ;

FOLKERS, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 42 (05) :806-&

[2] NEW HYDROXYQUINONES APPARENT INHIBITORS OF COENZYME Q ENZYME SYSTEMS [J].

CATLIN, JC ;

PARDINI, RS ;

DAVES, GD ;

HEIDKER, JC ;

FOLKERS, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (13) :3572-&

[3] EVIDENCE FOR THE EXTRACELLULAR REDUCTION OF FERRICYANIDE BY RAT-LIVER - A TRANS-PLASMA MEMBRANE REDOX SYSTEM [J].

CLARK, MG ;

PARTICK, EJ ;

PATTEN, GS ;

CRANE, FL ;

LOW, H ;

GREBING, C .

BIOCHEMICAL JOURNAL, 1981, 200 (03) :565-572

[4]

Crane F.L., 1977, BIOMEDICAL CLIN ASPE, P3

[5]

CRANE FL, 1988, PLASMA MEMBRANE OXID

[6]

GARCIACANERO R, 1987, REDOX FUNCTIONS EUKA, P43

[7]

HORGAN DJ, 1968, J BIOL CHEM, V243, P834

[8] INTRACELLULAR DISTRIBUTION OF COENZYME Q IN RAT LIVER [J].

JAYARAMAN, J ;

RAMASARMA, T .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1963, 103 (02) :258-&

[9]

KALIN A, 1987, BIOCHIM BIOPHYS ACTA, V926, P70

[10] NONHEME COMPLEXES OF FEIII STIMULATE CELL ATTACHMENT AND GROWTH BY A MECHANISM DIFFERENT FROM THAT OF SERUM, 2-OXOCARBOXYLATES, AND HEMEPROTEINS [J].

KAY, GF ;

ELLEM, KAO .

JOURNAL OF CELLULAR PHYSIOLOGY, 1986, 126 (02) :275-284

← 1 2 3 →