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QUANTITATIVE-ANALYSIS OF ANTI-CYTOKININ ACTIVITY OF 4-SUBSTITUTED-2-METHYLTHIOPYRIDO[2,3-D]PYRIMIDINES
被引:25
作者
:
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
IWAMURA, H
[
1
]
MURAKAMI, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
MURAKAMI, S
[
1
]
KOGA, JI
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KOGA, JI
[
1
]
MATSUBARA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
MATSUBARA, S
[
1
]
KOSHIMIZU, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KOSHIMIZU, K
[
1
]
机构
:
[1]
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
来源
:
PHYTOCHEMISTRY
|
1979年
/ 18卷
/ 08期
关键词
:
Anticytokinins;
pyrido[2,3-d]pyrimidines;
structure-activity relationship;
tobacco callus;
D O I
:
10.1016/0031-9422(79)83004-6
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Ten 4-substituted-2-methylthiopyrido[2,3-d]pyrimidines were synthesized and tested for their cytokinin-antagonistic activity by the tobacco callus bioassay. This series of compounds constitutes the first example of anti-cytokinins which possess a fused 6-6 membered ring system. The treatment of Lineweaver and Burk, the method of classical enzyme kinetics, revealed competitive inhibition of cytokinin-induced tobacco callus growth. The variation of activity with the systematic transformation of 4-substituents was analysed quantitatively with physicochemical substituent parameters and regression analysis. The results indicated the predominant importance of substituent width for binding of the antagonists at the receptor site of cytokinins. © 1979.
引用
收藏
页码:1265 / 1268
页数:4
相关论文
共 15 条
[1]
CYTOKININS - DEVELOPMENT OF A POTENT ANTAGONIST
[J].
HECHT, SM
论文数:
0
引用数:
0
h-index:
0
HECHT, SM
;
BOCK, RM
论文数:
0
引用数:
0
h-index:
0
BOCK, RM
;
SCHMITZ, RY
论文数:
0
引用数:
0
h-index:
0
SCHMITZ, RY
;
SKOOG, F
论文数:
0
引用数:
0
h-index:
0
SKOOG, F
;
LEONARD, NJ
论文数:
0
引用数:
0
h-index:
0
LEONARD, NJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1971,
68
(10)
:2608
-&
[2]
HECHT SM, 1975, J BIOL CHEM, V250, P7343
[3]
ANTICYTOKININ ACTIVITY OF 4-FURFURYLAMINO-7-(BETA-D-RIBOFURANOSYL) PYRROLO[2,3-D] PYRIMIDINE
[J].
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
IWAMURA, H
;
ITO, T
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
ITO, T
;
KUMAZAWA, Z
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
KUMAZAWA, Z
;
OGAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
OGAWA, Y
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1974,
57
(02)
:412
-416
[4]
SYNTHESIS AND ANTICYTOKININ ACTIVITY OF 4-SUBSTITUTED-7-(BETA-D-RIBOFURANOSYL)-PYRROLO[2,3-D]PYRIMIDINES
[J].
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
IWAMURA, H
;
ITO, T
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
ITO, T
;
KUMAZAWA, Z
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
KUMAZAWA, Z
;
OGAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
OGAWA, Y
.
PHYTOCHEMISTRY,
1975,
14
(11)
:2317
-2321
[5]
CYTOKININ-AGONISTIC AND ANTAGONISTIC ACTIVITIES OF 4-SUBSTITUTED-2-METHYLPYRROLO[2,3-D]PYRIMIDINES, 7-DEAZA ANALOGS OF CYTOKININ-ACTIVE ADENINE-DERIVATIVES
[J].
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
IWAMURA, H
;
MASUDA, N
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
MASUDA, N
;
KOSHIMIZU, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KOSHIMIZU, K
;
MATSUBARA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
MATSUBARA, S
.
PHYTOCHEMISTRY,
1979,
18
(02)
:217
-222
[6]
SUBSTITUENT CONSTANTS FOR ALIPHATIC FUNCTIONS OBTAINED FROM PARTITION COEFFICIENTS
[J].
IWASA, J
论文数:
0
引用数:
0
h-index:
0
IWASA, J
;
FUJITA, T
论文数:
0
引用数:
0
h-index:
0
FUJITA, T
;
HANSCH, C
论文数:
0
引用数:
0
h-index:
0
HANSCH, C
.
JOURNAL OF MEDICINAL CHEMISTRY,
1965,
8
(02)
:150
-&
[7]
The determination of enzyme dissociation constants
[J].
Lineweaver, H
论文数:
0
引用数:
0
h-index:
0
机构:
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Lineweaver, H
;
Burk, D
论文数:
0
引用数:
0
h-index:
0
机构:
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Burk, D
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1934,
56
:658
-666
[8]
ORGANIC GROWTH FACTOR REQUIREMENTS OF TOBACCO TISSUE CULTURES
[J].
LINSMAIER, EM
论文数:
0
引用数:
0
h-index:
0
LINSMAIER, EM
;
SKOOG, F
论文数:
0
引用数:
0
h-index:
0
SKOOG, F
.
PHYSIOLOGIA PLANTARUM,
1965,
18
(01)
:100
-+
[9]
CHEMICAL STRUCTURE AND ANTIAUXIN ACTIVITY
[J].
MCRAE, DH
论文数:
0
引用数:
0
h-index:
0
MCRAE, DH
;
BONNER, J
论文数:
0
引用数:
0
h-index:
0
BONNER, J
.
PHYSIOLOGIA PLANTARUM,
1953,
6
(03)
:485
-510
[10]
STUDIES ON CONDENSED PYRIMIDINE SYSTEMS .12. SYNTHESIS OF SOME 4-SUBSTITUTED AND 2,4-SUBSTITUTED PYRIDO [2,3-D]PYRIMIDINES
[J].
ROBINS, RK
论文数:
0
引用数:
0
h-index:
0
ROBINS, RK
;
HITCHINGS, GH
论文数:
0
引用数:
0
h-index:
0
HITCHINGS, GH
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1955,
77
(08)
:2256
-2260
←
1
2
→
共 15 条
[1]
CYTOKININS - DEVELOPMENT OF A POTENT ANTAGONIST
[J].
HECHT, SM
论文数:
0
引用数:
0
h-index:
0
HECHT, SM
;
BOCK, RM
论文数:
0
引用数:
0
h-index:
0
BOCK, RM
;
SCHMITZ, RY
论文数:
0
引用数:
0
h-index:
0
SCHMITZ, RY
;
SKOOG, F
论文数:
0
引用数:
0
h-index:
0
SKOOG, F
;
LEONARD, NJ
论文数:
0
引用数:
0
h-index:
0
LEONARD, NJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1971,
68
(10)
:2608
-&
[2]
HECHT SM, 1975, J BIOL CHEM, V250, P7343
[3]
ANTICYTOKININ ACTIVITY OF 4-FURFURYLAMINO-7-(BETA-D-RIBOFURANOSYL) PYRROLO[2,3-D] PYRIMIDINE
[J].
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
IWAMURA, H
;
ITO, T
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
ITO, T
;
KUMAZAWA, Z
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
KUMAZAWA, Z
;
OGAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR SCI,TSU 514,MIE,JAPAN
OGAWA, Y
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1974,
57
(02)
:412
-416
[4]
SYNTHESIS AND ANTICYTOKININ ACTIVITY OF 4-SUBSTITUTED-7-(BETA-D-RIBOFURANOSYL)-PYRROLO[2,3-D]PYRIMIDINES
[J].
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
IWAMURA, H
;
ITO, T
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
ITO, T
;
KUMAZAWA, Z
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
KUMAZAWA, Z
;
OGAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
MIE UNIV,DEPT AGR CHEM,TSU 514,MIE,JAPAN
OGAWA, Y
.
PHYTOCHEMISTRY,
1975,
14
(11)
:2317
-2321
[5]
CYTOKININ-AGONISTIC AND ANTAGONISTIC ACTIVITIES OF 4-SUBSTITUTED-2-METHYLPYRROLO[2,3-D]PYRIMIDINES, 7-DEAZA ANALOGS OF CYTOKININ-ACTIVE ADENINE-DERIVATIVES
[J].
IWAMURA, H
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
IWAMURA, H
;
MASUDA, N
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
MASUDA, N
;
KOSHIMIZU, K
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KOSHIMIZU, K
;
MATSUBARA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
KYOTO PREFECTURAL UNIV,APPL BIOL LAB,KYOTO 606,JAPAN
MATSUBARA, S
.
PHYTOCHEMISTRY,
1979,
18
(02)
:217
-222
[6]
SUBSTITUENT CONSTANTS FOR ALIPHATIC FUNCTIONS OBTAINED FROM PARTITION COEFFICIENTS
[J].
IWASA, J
论文数:
0
引用数:
0
h-index:
0
IWASA, J
;
FUJITA, T
论文数:
0
引用数:
0
h-index:
0
FUJITA, T
;
HANSCH, C
论文数:
0
引用数:
0
h-index:
0
HANSCH, C
.
JOURNAL OF MEDICINAL CHEMISTRY,
1965,
8
(02)
:150
-&
[7]
The determination of enzyme dissociation constants
[J].
Lineweaver, H
论文数:
0
引用数:
0
h-index:
0
机构:
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Lineweaver, H
;
Burk, D
论文数:
0
引用数:
0
h-index:
0
机构:
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Bur Chem & Soils, Fertilizer Invest Unit, US Dept Agr, Washington, DC USA
Burk, D
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1934,
56
:658
-666
[8]
ORGANIC GROWTH FACTOR REQUIREMENTS OF TOBACCO TISSUE CULTURES
[J].
LINSMAIER, EM
论文数:
0
引用数:
0
h-index:
0
LINSMAIER, EM
;
SKOOG, F
论文数:
0
引用数:
0
h-index:
0
SKOOG, F
.
PHYSIOLOGIA PLANTARUM,
1965,
18
(01)
:100
-+
[9]
CHEMICAL STRUCTURE AND ANTIAUXIN ACTIVITY
[J].
MCRAE, DH
论文数:
0
引用数:
0
h-index:
0
MCRAE, DH
;
BONNER, J
论文数:
0
引用数:
0
h-index:
0
BONNER, J
.
PHYSIOLOGIA PLANTARUM,
1953,
6
(03)
:485
-510
[10]
STUDIES ON CONDENSED PYRIMIDINE SYSTEMS .12. SYNTHESIS OF SOME 4-SUBSTITUTED AND 2,4-SUBSTITUTED PYRIDO [2,3-D]PYRIMIDINES
[J].
ROBINS, RK
论文数:
0
引用数:
0
h-index:
0
ROBINS, RK
;
HITCHINGS, GH
论文数:
0
引用数:
0
h-index:
0
HITCHINGS, GH
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1955,
77
(08)
:2256
-2260
←
1
2
→