BILE-ACIDS .81. SYNTHESIS AND STRUCTURAL ASSIGNMENT OF E/Z ISOMERS OF SUBSTITUTED METHYL HYDROXY-5-BETA-CHOLEST-24-EN-26-OATES

被引：6

作者：

IQBAL, MN ^{[1
]}

PATRICK, PH ^{[1
]}

ELLIOTT, WH ^{[1
]}

机构：

[1] ST LOUIS UNIV,SCH MED,EDWARD A DOISY DEPT BIOCHEM & MOLEC BIOL,1402 S GRAND BLVD,ST LOUIS,MO 63104

来源：

STEROIDS | 1991年 / 56卷 / 10期

关键词：

STEROIDS; BILE ACIDS; C27 BILE ACIDS; MASS SPECTROMETRY; 5-BETA-CHOLEST-24-EN-26-OATES; E/Z ISOMERS; BILE ACID PRECURSORS;

D O I：

10.1016/0039-128X(91)90115-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syntheses of the E and Z isomers of methyl 3-alpha-, 3-alpha,7-alpha-, 3-alpha,12-alpha-, and 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-en-26-oates are reported. Mass spectral studies show fragmentation patterns in support of assignment as the E or Z isomers, especially in differences in loss of the side chain. Chromatographic procedures, primarily gas chromatography and high-performance liquid chromatography, support these assignments. The E isomer predominates in either of two methods of synthesis.

引用

页码：505 / 512

页数：8

共 20 条

[1]

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[2]

BJORKHEM I, 1985, STEROLS BILE ACIDS, P231

[3]

Budzikiewicz H, 1972, BIOCH APPLICATIONS M, P251

[4]

ELLIOTT WH, 1972, BIOCH APPLICATIONS M, P291