ASSIGNMENT OF THE HUMAN STROMELYSIN-3 (STMY3) GENE TO THE Q11.2 REGION OF CHROMOSOME-22

被引：28

作者：

LEVY, A

ZUCMAN, J

DELATTRE, O

MATTEI, MG

RIO, MC

BASSET, P

机构：

[1] FAC MED STRASBOURG,INST CHIM BIOL,CNRS,GENET MOLEC EUCARYOTES LAB,INSERM,U184,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE

[2] GRP HOSP TIMONE,HOP ENFANTS,INSERM,U242,UNITE PHYSIOPATHOL CHROMOSOM,F-13385 MARSEILLE 05,FRANCE

[3] INST CURIE,BIOL SECT,F-75231 PARIS 05,FRANCE

来源：

GENOMICS | 1992年 / 13卷 / 03期

关键词：

D O I：

10.1016/0888-7543(92)90175-R

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The human stromelysin 3 (STMY3) gene, a new member of the matrix metalloproteinase (MMP) gene family, may contribute to breast cancer cell invasion, and has been localized by in situ hybridization to the long arm of chromosome 22. As demonstrated using a panel of somatic cell hybrids, the STMY3 gene is in band 22q11.2, in close proximity to the BCR gene involved in chronic myeloid leukemia, but far from the (11;22) translocation breakpoint observed in Ewing sarcoma. This position differs from that reported on chromosomes 11 and 16 for the other MMP genes, suggesting that stromelysin 3 could be a member of a new MMP subfamily. © 1992.

引用

页码：881 / 883

页数：3

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