LIQUID-CHROMATOGRAPHIC SEPARATION OF CHIRAL DIARYLCARBINOLS

被引：4

作者：

CACCAMESE, S

MACCAGNANO, MG

机构：

[1] Dipartimento di Scienze Chimiche, Università di Catania, Catania

来源：

CHIRALITY | 1992年 / 4卷 / 03期

关键词：

CHIRAL PHASES; CHIRAL RECOGNITION MECHANISM; ALCOHOLS;

D O I：

10.1002/chir.530040307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The direct HPLC separation of three chiral carbinols of general formula Mesityl-CH(OH)-Aryl has been achieved using Pirkle (R)-DNBPG ionic or covalent columns and, for Aryl = o-tolyl, on a Chiralpak OP(+) phase. It is apparent that steric hindrance and hydrogen bonding play important roles in chiral recognition. Two compounds structurally very similar but lacking the hydroxyl group were not resolved in their enantiomeric pairs.

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页码：170 / 173

页数：4

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