ALARM SUBSTANCE INDUCES CONVULSIONS IN IMIPRAMINE-TREATED RATS

被引：10

作者：

ABEL, EL

BILITZKE, PJ

COTTON, DB

机构：

[1] WAYNE STATE UNIV,DEPT OBSTET & GYNECOL,DETROIT,MI 48201

[2] WAYNE STATE UNIV,FETAL ALCOHOL RES CTR,DETROIT,MI 48201

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 41卷 / 03期

关键词：

CONVULSIONS; IMIPRAMINE; ALARM SUBSTANCE; STRESS; ADRENALECTOMY;

D O I：

10.1016/0091-3057(92)90378-S

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Male rats were injected with imipramine (0-30 mg/kg) and subsequently tested in the forced-swim test in either fresh water or water soiled by other rats, which presumably contains an alarm substance. Imipramine did not affect the behavior of rats in fresh water. More than half the animals given the combination of imipramine (30 mg/kg) and stress from alarm substance had clonic convulsions. Adrenalectomy did not affect this relationship. This is the first study demonstrating the potential of an alarm substance for inducing convulsions.

引用

页码：599 / 601

页数：3

共 37 条

[1] A POSSIBLE ALARM SUBSTANCE IN THE FORCED SWIMMING TEST [J].