CLONING AND EXPRESSION OF A NOVEL HUMAN PROFILIN VARIANT, PROFILIN-II

被引：73

作者：

HONORE, B ^{[1
]}

MADSEN, P ^{[1
]}

ANDERSEN, AH ^{[1
]}

LEFFERS, H ^{[1
]}

机构：

[1] AARHUS UNIV, DANISH CTR HUMAN GENOME RES, DK-8000 AARHUS, DENMARK

来源：

FEBS LETTERS | 1993年 / 330卷 / 02期

关键词：

PROFILIN VARIANT; CDNA CLONING; TISSUE EXPRESSION; HOMO-SAPIENS;

D O I：

10.1016/0014-5793(93)80262-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a 1.7 kbp cDNA encoding a 140 amino acid protein (15.1 kDa, pI 5.9 1) with a high sequence similarity (62%) to human profilin (profilin I). We have termed this variant profilin II. Northern blot analysis showed that profilin II is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. In addition, three different transcript lengths were detected. Only one transcript of profilin I was found. The expression level of this was low in brain and skeletal muscle, medium in heart and high in placenta, lung, liver and kidney.

引用

页码：151 / 155

页数：5

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