THE STRUCTURE OF NEUTROPHIL DEFENSIN GENES

被引：57

作者：

LINZMEIER, R ^{[1
]}

MICHAELSON, D ^{[1
]}

LIU, L ^{[1
]}

GANZ, T ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, WILL ROGERS INST PULM, RES LAB, LOS ANGELES, CA USA

来源：

FEBS LETTERS | 1993年 / 321卷 / 2-3期

关键词：

NEUTROPHIL; GENE STRUCTURE; DEFENSIN;

D O I：

10.1016/0014-5793(93)80122-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defensins are a family of microbicidal peptides abundant in the granules of mammalian neutrophils, in rabbit alveolar macrophages, and in human and murine intestinal Paneth cells. We cloned and sequenced the genes of three neutrophil-specific defensins. Human HNP-1 and HNP-3 are nearly identical and rabbit NP-3a is closely related. The four known neutrophil-specific defensin genes are strikingly similar in the structure and organization of their three exons and two introns, but the three defensin genes expressed in macrophages (MCP-1 and -2) or Paneth cells (HD-5) are organized differently: HD-5 has only two exons, and MCP-1 and -2 have a comparatively short first intron. The diverse genomic organization of defensin genes may contribute to their cell-specific expression.

引用

页码：267 / 273

页数：7

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