CHARACTERIZATION OF EPITOPES RECOGNIZED BY CANDIDA FACTOR-I AND FACTOR-IX ANTISERA BY USE OF SACCHAROMYCES-CEREVISIAE MNN MUTANTS

被引：20

作者：

ATAOGLU, H ^{[1
]}

ZUECO, J ^{[1
]}

SENTANDREU, R ^{[1
]}

机构：

[1] UNIV VALENCIA, FAC FARM, DEPT MICROBIOL, AVGDA VICENT ANDRES ESTELLES S-N, E-46100 BURJASSOT, SPAIN

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 08期

关键词：

D O I：

10.1128/IAI.61.8.3313-3317.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of Saccharomyces cerevisiae mnn mutants has facilitated the study of the epitopes recognized by antisera against several antigenic factors of the genus Candida (Candida Check; Iatron Laboratories, Tokyo, Japan). We have taken advantage of the very well characterized structure of the mannans of the different mnn mutants to compare their reactivities with the factor antisera used in the identification of different species of the genus Candida. The results of this study provide evidence that one of the antigenic determinants recognized by factor 1 antisera is the 0-linked mannose chains of the cell wall mannoproteins, while that recognized by factor 9 antiserum is the alpha1-6-linked mannose backbone of the outer chain of the N-linked oligosaccharide.

引用

页码：3313 / 3317

页数：5

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