SERUM TRACE-METALS IN CHRONIC VIRAL-HEPATITIS AND HEPATOCELLULAR-CARCINOMA IN THAILAND

被引：40

作者：

PRAMOOLSINSAP, C

PROMVANIT, N

KOMINDR, S

LERDVERASIRIKUL, P

SRIANUJATA, S

机构：

[1] Division of Gastroenterology, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Rama IV

[2] Research Center, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Rama IV

[3] Division of Nutrition, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Rama IV

来源：

JOURNAL OF GASTROENTEROLOGY | 1994年 / 29卷 / 05期

关键词：

CHRONIC LIVER DISEASE; SERUM ZINC; SERUM COPPER;

D O I：

10.1007/BF02365444

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study was conducted to determine and compare serum trace metal levels in viral hepatitis-associated chronic liver disease. Of 98 patients aged 43 (+/- 13) [mean (+/- SD)] years, 83 (85%) were seropositive for hepatitis B surface antigen (HBsAg) and 15 (15%) were seropositive for anti-hepatitis C virus (HCV). Twenty-five patients had chronic persistent hepatitis, 32 chronic active hepatitis, 21 post-necrotic cirrhosis, and 20 hepatocellular carcinoma. Determination of fasting serum trace metal levels (zinc, copper, calcium, magnesium, and phosphorus) was performed after the patients had been on a 2-day diet containing 10-12 mg zinc/day. Compared to healthy volunteers (n = 30), serum zinc levels were significantly decreased in patients with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma (P less-than-or-equal-to 0.0001), and copper levels were significantly elevated only in patients with hepatocellular carcinoma (P < 0.0001). The overall serum levels of calcium, magnesium, and phosphorus were within normal ranges, and levels of calcium and magnesium correlated with serum zinc (P = 0.01-0.03). Serum zinc levels correlated with bilirubin, albumin, and cholesterol (P = 0.0004 less-than-or-equal-to 0.0001), but not with daily urinary zinc excretion. Serum copper levels correlated with alkaline phosphatase and gamma-glutamyltransferase (P = 0.008-0.0001). These results suggested that changes in liver cell pathology compounded by functional impairment may alter the metabolism of trace metals, in particular, zinc and copper. The possible relationship of these changes to the pathogenesis of chronic liver disease is discussed.

引用

页码：610 / 615

页数：6

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