SPONTANEOUS AND INDUCED REVERSION OF ICR-170-INDUCED XANTHINE DEHYDROGENASE MUTANTS OF ASPERGILLUS-NIDU-LANS

被引：7

作者：

ALDERSON, T

机构：

[1] Department of Genetics, University of Cambridge Great Britain

来源：

MUTATION RESEARCH | 1969年 / 8卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0027-5107(69)90069-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

ICR-170-induced xanthine dehydrogenase (XDH) mutants occuring at 6 independent gene loci in Aspergillus have been examined for their ability to revert spontaneously, and after treatments with ICR-170, diethyl sulphate (DES), and N-methyl-N-nitroso-N′-nitroguanidine (NG). The results are discussed in relation to studies of the revertibility of previously characterised adenine-3B Neurospora mutants by ICR-170, which indicate that ICR-170 produces predomonantly base-pair insertion or deletion mutations in DNA. Little or no evidence is found that ICR-170 induces this type of molecular change in Aspergillus. An analysis of variance on the revertible ICR-170-induced XDH mutants indicates no significant effect on gene locus or reverting mutagen on reversion (by ICR-170, DES and NG). © 1969.

引用

页码：521 / &

共 13 条

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