NEURAL TRANSPLANTATION USING TEMPERATURE-SENSITIVE IMMORTALIZED NEURAL CELLS - A PRELIMINARY-REPORT

被引:28
作者
BREDESEN, DE
HISANAGA, K
SHARP, FR
机构
[1] UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143
[2] VET ADM MED CTR,SAN FRANCISCO,CA 94121
关键词
D O I
10.1002/ana.410270218
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Current approaches to neural transplantation–adrenal medullary and fetal brain–suffer from limitations in tissue availability, cellular uniformity, and general applicability. The system described here uses temperature‐sensitive immortalized clonal neural cells to address these limitations. Cerebellar cells, immortalized with a temperature‐sensitive tumor virus, are transformed at 34°C, but differentiate at 38°C. The cells were genetically engineered to express beta‐galactosidase, providing a tag to study their fate in the host. The cells were then successfully transplanted to the cerebellum of adult rats. Copyright © 1990 American Neurological Association
引用
收藏
页码:205 / 207
页数:3
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