HYPERAMINOACIDEMIA IN EPILEPTIC CHILDREN TREATED WITH VALPROIC ACID

被引：9

作者：

CASTROGAGO, M ^{[1
]}

RODRIGOSAEZ, E ^{[1
]}

NOVORODRIGUEZ, I ^{[1
]}

CAMINA, MF ^{[1
]}

RODRIGUEZSEGADE, S ^{[1
]}

机构：

[1] UNIV SANTIAGO COMPOSTELA,HOSP CLIN UNIV,DEPT BIOQUIM,SERV LAB CENT,E-15705 SANTIAGO,SPAIN

来源：

CHILDS NERVOUS SYSTEM | 1990年 / 6卷 / 08期

关键词：

VALPROATE; HYPERAMINOACIDEMIA; CARNITINE; UREA CYCLE;

D O I：

10.1007/BF00302087

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serum amino acids were determined in 22 epileptic children treated with valproic acid. This treatment caused hypocarnitinemia in all, and hyperammonemia in 16. Regardless of the blood ammonia levels, values for glutamic acid, arginine, glycine, serine and alanine were higher than those of normal controls, while aspartic acid and ornithine were lower. These findings suggest that valproate causes intramitochondrial dysfunction of the urea cycle.

引用

页码：434 / 436

页数：3

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