PARTIAL TRISOMY-1 DUE TO 1/17 TRANSLOCATION IN PH'-POSITIVE CHRONIC MYELOCYTIC-LEUKEMIA

被引：23

作者：

PASQUALI, F ^{[1
]}

FRANCESCONI, D ^{[1
]}

CASALONE, R ^{[1
]}

IPPOLITI, G ^{[1
]}

机构：

[1] UNIV PAVIA,MED CLIN A FERRATA 1,I-27100 PAVIA,ITALY

来源：

HUMAN GENETICS | 1979年 / 49卷 / 03期

关键词：

D O I：

10.1007/BF00569347

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A patient with chronic myelocytic leukaemia (CML) had the Philadelphia chromosome from the standard 9/22 translocation, a partial trisomy 1 secondary to an unbalanced 1/17 translocation, and a more recent clone with the addition of trisomy 22. This is the third case of partial trisomy 1 associated with the Philadelphia chromosome. Trisomy 1 in haematological disorders is discussed with reference to its clinical significance in CML, the segment of chromosome no. 1 involved, and the mechanisms of origin of the partial trisomies. Anomalies of chromosome 1, although not specific to any of them, seem to be important in the development of myeloproliferative disorders and of neoplasms in general. © 1979 Springer-Verlag.

引用

页码：277 / 282

页数：6

共 19 条

[1] CHROMOSOMES-1 IN 14 OVARIAN CANCERS - HETEROCHROMATIN VARIANTS AND STRUCTURAL-CHANGES [J].