LONG-TERM FOLLOW-UP TREATMENT WITH SABELUZOLE IN ELDERLY PATIENTS WITH PRONOUNCED MEMORY PROBLEMS OF UNKNOWN ORIGIN

In an open follow-up study, 31 elderly patients with real memory problems of unknown origin were treated for at least 10 months with sabeluzole 10 mg b.i.d. Not only were the same improvements seen as in the preceding double-blind trial on the cued recall task (CRT) and the word fluency test (WF), but additionally, significantly better results were obtained for the selective reminding procedure after this long-term treatment: all quantitative (total recall, long-term storage [LTS], long-term retrieval [LTR], consistent long-term retrieval [cLTR]) and qualitative (LTR/total recall, cLTR/total recall) parameters improved in this task. The objective effects were again accompanied by a subjective improvement as reported by the patients and their physician.